Search results for "Oral TTV DNA shedding"

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Kinetics of torque teno virus DNA load in saliva and plasma following allogeneic hematopoietic stem cell transplantation

2018

Plasma torque teno virus (TTV) DNA load directly correlates with the degree of T-cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution after engraftment. This prospective observational study enrolled 38 nonconsecutive allo-HSCT recipients. Saliva and plasma specimens were collected at baseline (pretransplant) and at around days +30, +50, and +90 after allo-HSCT. TTV DNA was quantitated in both specimen types by real-time PCR. ALCs were m…

AdultMale0301 basic medicineTorque teno virusSalivaOral TTV DNA sheddingLymphocytemedicine.medical_treatmentTTV DNAemiaAllogeneic hematopoietic stem cell transplantation (allo-HSCT)Hematopoietic stem cell transplantationReal-Time Polymerase Chain ReactionTorque teno virus (TTV)Plasma03 medical and health sciences0302 clinical medicineImmune systemVirologymedicineHumansTransplantation HomologousProspective StudiesAllogeneic hematopoietic stem cell transplantation (allo-HSCT); Immune reconstitution; Oral TTV DNA shedding; Saliva; Torque teno virus (TTV); TTV DNAemia; Virology; Infectious DiseasesSalivaAgedTorque teno virusbusiness.industryHematopoietic Stem Cell TransplantationMiddle AgedImmune reconstitutionVirologyDNA Virus InfectionsTransplantation030104 developmental biologyInfectious Diseasesmedicine.anatomical_structureReal-time polymerase chain reactionDNA ViralFemalebusinessCytometry030215 immunologyJournal of Medical Virology
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